Table 1.
| Stem Cell Type | Pretreatment | Species | Cell Status at Transplant | Delivery | Tracking | Heart Injury | Function Improvement | Cell Fate | Reference |
|---|---|---|---|---|---|---|---|---|---|
| P19CL6 | Cardiac Troponin I- interacting kinase gene (TNNI3K) + DMSO | M/M | CM | CI | E | Occlusion | + | ND | 1 |
| ESC | LIF and BMP-2 | M/M | CM | CI | V | Occlusion | + | CM, EC | 2 |
| ESC | Activin A and BMP-4 | H/R | CM | CI | I | Occlusion | + | CM | 3 |
| ESC | BMP-2 and FGFR inhibitor | H/R | CM | CI | I | Occlusion | ND | CM | 4 |
| ESC | TGFB-1, BMP-2 and -4, activin-A, FGF-2 and -4, IGF-1 and -2, VEGF-A, EGF, TNFα | M/M | CM | CI | I | Normal | ND | CM | 5 |
| ESC | 5-Azacytidine, allopurinol and ibuprofen orally | H/M | CM | CI | V | Occlusion | + | CM | 6 |
| ESC | LIF and BMP-2 | M/S | CM | CI | E | Occlusion | + | CM | 7 |
| ESC | TGFbeta | M/M | SC | CI | E | Occlusion | + | CM | 8 |
| ESC | IGF-1 | M/M | SC | CI | E | Occlusion | = | CM | 9 |
| ADSC | 5-Azacytidine | M/R | CM | CI | T | Occlusion | E | UD | 10 |
| MSC | FGF-2, IGF-1, BMP-2 | R/R | CM | CI | D | Occlusion | + | CM | 11 |
| MSC | Myocardin AdenoVirus | H/M | SC | CI | V | Occlusion | + | CM | 12 |
| MSC | HCN gene | H/D | SC | CI | E | Ablation | + | ND | 13 |
| MSC | 5-Azacytidine | R/R | CM | IV | D | Occlusion | ND | CM | 16 |
| FMhMSCs | mixed ester of hyaluronan with butyric and retinoic acid | H/R | CM | CI | I | Occlusion | = | CM, EC | 17 |
| MPC | 5-Azacytidine | M/M | CM | CI | V | Occlusion | + | CM | 18 |
| MSC | 5-Azacytidine | M/M | CM | CI | Li, V | Normal | ND | CM | 19 |
| MSC | FGF-2, IGF-1, BMP-2 | D/D | CM | CI | D | Occlusion | + | CM | 21 |
| BMC | VEGF, IGF-1 gene | R/R | CM | IV | CH | Occlusion | + | ND | 23 |
| BMC | TGF-beta | M/M | CM | CI | T | Occlusion | + | CM | 24 |
Cell Type: ESC-embryonic stem cells; ADSC-adipose derived stem cells; MSC-mesenchymal stem cells; MPC-mesenchymal progenitor cells; FMhMSCs-fetal membranes of term placenta; BMC-bone marrow cells
Species: H-Human; M-Mouse; R-Rat; D-Dog
Cell status at transplant: CM-cardiomyocyte; SC-stem cell
Delivery: CI-cardiac injection; IV-intravenously
Tracking: E-electroporation; V-viral transfection; I-immunostain; T-transgenic; D-dye; Li-liposome gene delivery; CH-Y chromosome
Functional Improvement: +-improved; ND-not determined; =/-no improvement
Cell Fate: ND-not determined; CM-cardiomyocyte; EC-endothelial cell