Skip to main content
. Author manuscript; available in PMC: 2010 Jul 23.
Published in final edited form as: J Med Chem. 2009 Jul 23;52(14):4533–4537. doi: 10.1021/jm900380j

Figure 4.

Figure 4

Docking conformations of 6 in (A) the active site of WT rat nNOS and (B) the L337H mutant rat nNOS. Inhibitor 6 is colored blue. Cofactors heme and H4B are shown in gray and purple, respectively. The potential H-bonds are indicated by dotted lines. Residue Asp597 of wild-type rat nNOS, which determines the selectivity between nNOS and eNOS, is colored green. The corresponding residue in bovine eNOS is Asn368.