Figure 1.

A broad overview of the anatomy of the sensory apparatus (thermo- and mechanosensory). Neurogenesis pertaining to the PNS in the developing mouse begins when the first-order sensory neurons located at the periphery of the spine extend and branch towards the periphery. Diagramed here are large and medium diameter neurons (in red) and small diameter neurons (in blue) terminating at the epidermis (in green are the mechanoreceptors and in tan are the sweat glands). Once the stimulus is received at the periphery, transmission from the first-order sensory neurons to the second-order sensory neurons (located in the dorsal horn of the spinal cord in gray) receive the information, which is then relayed to the brain (in pink), specifically the thalamus, to be translated by the third-order sensory neurons.