Table 2.

Mouse models of human disease with thermo/mechanosensory defects

Gene	Phenotype	Disease model	Reference
Apoe	Abnormal thermal nociception	Alzheimer disease (AD; OMIM ID 104300)	(100)
Clcn6	Increased thermal threshold	Ceroid lipofuscinosis, neuronal, 3 (CLN3; OMIM ID 204200)	(101)
Ctsc	Increased thermal threshold	Schizophrenia (SCZD; OMIM ID 181500)	(102)
Ndn	Decreased thermal threshold	Prader–Willi syndrome (PWS; OMIM ID 176270)	(44)
Ntrk1	Increased thermal threshold; unresponsive to tactile stimuli	Insensitivity to pain, congenital, with anhidrosis (CIPA; OMIM ID 256800)	(103)
Prx	Decreased thermal threshold; Hyporesponsive to tactile stimuli	Hypertrophic neuropathy of Dejerine–Sottas (OMIM ID 145900)	(104)
Bbs2	Hyporesponsive to tactile stimuli	Bardet–Biedl syndrome (BBS; OMIM ID 209900)	(105)
Bbs4	Hyporesponsive to tactile stimuli	Bardet–Biedl syndrome (BBS; OMIM ID 209900)	(18)
Kif1b	Unresponsive to tactile stimuli	Charcot–Marie–Tooth disease, axonal, type 2a1 (CMT2A1; OMIM ID 118210)	(106)
Trpv4	Abnormal response to tactile stimuli	Deafness, autosomal dominant nonsyndromic sensorineural 25 (DFNA25; OMIM ID 605583)	(102,107)