Table 3.
Ciliary genes associated with thermo/mechanosensory deficits
| Ciliary genes | Phenotype | Associated disorder | Reference |
|---|---|---|---|
| Gabrb3 | Increased nociception | Autism | (108,109) |
| Gabbr1 | Increased nociception (hyporesponsive mechanosensation) | Epilepsy | (110,111) |
| Dbh | Increased nociception | ADHD | (112) |
| Anxa1 | Increased nociception | ||
| Uchl1 | Increased nociception | PD | (102) |
| Ncam1 | Increased nociception | Bipolar disorder | (113) |
| Kcnk2 | Increased nociception | ||
| Kcna1 | Decreased nociception | ||
| Htr1b | Increased nociception | ||
| Gria2 | Increased nociception | ||
| Gnao1 | Decreased nociception | ||
| Syn2 | Decreased nociception | Susceptibility to schizophrenia | (102,114) |
| Slc6a1 | Decreased nociception | ||
| Slc12a5 | Decreased nociception | ||
| Slc12a2 | Decreased nociception | Deafness | (115) |
| Scn9a | Increased nociception | Erythermalgia/paroxysmal extreme pain disorder | (116–118) |
| Scn10a | Decreased nociception | ||
| Prkar1b | Decreased nociception | ||
| Plcb4 | Decreased nociception | ||
| Npepps | Increased nociception | ||
| Kif1a | Decreased nociception | ||
| Hmox2 | Decreased nociception | ||
| Gucy1b3 | Decreased nociception | ||
| Fmr1 | Decreased nociception | Fragile X mental retardation | (119–121) |
| Faah | Decreased nociception | Obesity | (122) |
| Dlg2 | Decreased nociception | ||
| Camk2a | Decreased nociception | ||
| Cacna1h | Decreased nociception | Epilepsy | (123–125) |
| Cacna1b | Decreased nociception | ||
| Bbs4 | Decreased nociception | BBS | (18) |
| Bbs1 | Decreased nociception | BBS | (18) |
| Fxr2 | Increased thermosensation | ||
| Gria3 | Increased thermosensation | ||
| Atp1a2 | Unresponsive mechanosensation | Familial hemiplegic migraine | (126) |
| Bbs2 | Hyporesponsive mechanosensation | BBS | (105) |
| Cacna1a | Hyporesponsive mechanosensation | SCA6 | (79–81) |
| Flnc | Hyporesponsive mechanosensation | ||
| Gna11 | Hyporesponsive mechanosensation | ||
| Gnaq | Hyporesponsive mechanosensation | ||
| Madd | Hyporesponsive mechanosensation | ||
| Snap25 | Unresponsive mechanosensation | ADHD | (127) |
| Ncs1 | Thermosensationtaxis | ||
| Unc97 | Abnormal mechanosensation | ||
| Sptlc1 | Decreased nociception | Neuropathy type I/HSAN1 | (71–76) |
| Ikbkap | Decreased nociception | Neuropathy type III/ HSAN3 | (77,78) |