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. 2009 Sep 15;5:304. doi: 10.1038/msb.2009.53

Table 1.

List of candidate loci associated with AD from the 22 autosome of the AD SNP genotype data (Coon et al, 2007)

CHR SNP ID Locationa Function Gene Gene ID Effect
aIn nucleotide basepair.
bLoci remained in the model on logistic regression selection with a P-value<0.05.
cLoci in homozygous regions containing candidate loci of recessive genetic lesion causing AD (Clarimón et al, 2008).
dGenes are on known functional pathways and networks as revealed by the use of Ingenuity Pathway Analysis (Ingenuity Systems, www.ingenuity.com).
eA SNP in Affymetrix 500K GeneChip, but without NCBI ID.
1 rs17325887b,c 69998761 Intron LRRC7d 57554 Risk
1 rs7520521c 70020703 Intron LRRC7d 57554 Risk
1 rs1913269b,c 70052194 Intron LRRC7d 57554 Risk
1 rs10754339b 117491795 mRNA–UTR VTCN1d 79679 Protect
1 rs16842422b 196366613 –66918 LOC647195 647195 Protect
2 rs7582851 192032391 –392328 LOC647167 647167 Protect
3 rs6784615b 52481466 Intron NISCHd 11188 Protect
4 rs9994615 40786592 Intron APBB2d 323 Risk
4 rs10015784b 40793978 Intron APBB2d 323 Risk
5 rs1602843b,c 86324342 0 COL24A1d 255631 Risk
5 rs2913719b 163947773 2403 LOC440700 440700 Protect
6 rs13213247b 81572755 –91974 LOC729817 729817 Risk
6 rs16892285 81592721 –72008 LOC729817 729817 Risk
6 rs13193950 81593433 –71296 LOC729817 729817 Risk
6 rs156232b 104979509 481535 LOC642337 642337 Risk
10 rs10827687b 36999313 –39887 GRIK3d 2899 Risk
10 rs10824310b 53698470 Intron PRKG1d 5592 Risk
10 rs10740548 54877234 –2797 C1orf175d 374977 Risk
11 rs1038891b,c 40895642 0 RIMS3d 9783 Risk
12 rs1354470b 59088188 –32939 LOC645757 645757 Risk
12 rs7967572 73396068 51514 KRT8P21 126811 Risk
18 rs1785928b 31979929 Coding non-synonymous ELP2d 55250 Risk
19 rs11879589 50065116 Intron PVRL2d 5819 Protect
19 rs4420638b 50114786 Locus region APOC1d 341 Protect
19 e 50150075        
19 rs204907 50153836 Intron CLPTM1d 1209 Protect