Table 1.
CHR | SNP ID | Locationa | Function | Gene | Gene ID | Effect |
---|---|---|---|---|---|---|
aIn nucleotide basepair. | ||||||
bLoci remained in the model on logistic regression selection with a P-value<0.05. | ||||||
cLoci in homozygous regions containing candidate loci of recessive genetic lesion causing AD (Clarimón et al, 2008). | ||||||
dGenes are on known functional pathways and networks as revealed by the use of Ingenuity Pathway Analysis (Ingenuity Systems, www.ingenuity.com). | ||||||
eA SNP in Affymetrix 500K GeneChip, but without NCBI ID. | ||||||
1 | rs17325887b,c | 69998761 | Intron | LRRC7d | 57554 | Risk |
1 | rs7520521c | 70020703 | Intron | LRRC7d | 57554 | Risk |
1 | rs1913269b,c | 70052194 | Intron | LRRC7d | 57554 | Risk |
1 | rs10754339b | 117491795 | mRNA–UTR | VTCN1d | 79679 | Protect |
1 | rs16842422b | 196366613 | –66918 | LOC647195 | 647195 | Protect |
2 | rs7582851 | 192032391 | –392328 | LOC647167 | 647167 | Protect |
3 | rs6784615b | 52481466 | Intron | NISCHd | 11188 | Protect |
4 | rs9994615 | 40786592 | Intron | APBB2d | 323 | Risk |
4 | rs10015784b | 40793978 | Intron | APBB2d | 323 | Risk |
5 | rs1602843b,c | 86324342 | 0 | COL24A1d | 255631 | Risk |
5 | rs2913719b | 163947773 | 2403 | LOC440700 | 440700 | Protect |
6 | rs13213247b | 81572755 | –91974 | LOC729817 | 729817 | Risk |
6 | rs16892285 | 81592721 | –72008 | LOC729817 | 729817 | Risk |
6 | rs13193950 | 81593433 | –71296 | LOC729817 | 729817 | Risk |
6 | rs156232b | 104979509 | 481535 | LOC642337 | 642337 | Risk |
10 | rs10827687b | 36999313 | –39887 | GRIK3d | 2899 | Risk |
10 | rs10824310b | 53698470 | Intron | PRKG1d | 5592 | Risk |
10 | rs10740548 | 54877234 | –2797 | C1orf175d | 374977 | Risk |
11 | rs1038891b,c | 40895642 | 0 | RIMS3d | 9783 | Risk |
12 | rs1354470b | 59088188 | –32939 | LOC645757 | 645757 | Risk |
12 | rs7967572 | 73396068 | 51514 | KRT8P21 | 126811 | Risk |
18 | rs1785928b | 31979929 | Coding non-synonymous | ELP2d | 55250 | Risk |
19 | rs11879589 | 50065116 | Intron | PVRL2d | 5819 | Protect |
19 | rs4420638b | 50114786 | Locus region | APOC1d | 341 | Protect |
19 | e | 50150075 | ||||
19 | rs204907 | 50153836 | Intron | CLPTM1d | 1209 | Protect |