Table 3.

Longitudinal proportional ORs (95% CI) for greater frailty status at visit 2, by level of various sex hormones at baseline in elderly men

	Q1	Q2	Q3	Q4	Pfor trend
E	<17.2 pg/ml	17.2 to <21.7 pg/ml	21.7 to <26.9 pg/ml	≥26.9 pg/ml
Age, baseline status adjusted	1.17 (0.87, 1.60)	0.99 (0.72, 1.34)	1.18 (0.83, 1.69)	1.00 (referent)	0.282
MV adjusted	1.12 (0.82, 1.53)	0.96 (0.70, 1.32)	0.97 (0.71, 1.32)	1.00 (referent)	0.517
Bioavailable E	<11.3 pg/ml	11.3 to <14.0 pg/ml	14.0 to <17.0 pg/ml	≥17.0 pg/ml
Age, baseline status adjusted	0.96 (0.70, 1.30)	0.99 (0.73, 1.34)	0.72 (0.53, 0.99)	1.00 (referent)	0.751
MV adjusted	0.92 (0.67, 1.25)	1.04 (0.76, 1.41)	0.71 (0.52, 0.97)	1.00 (referent)	0.852
T	<298 ng/dl	298 to <388 ng/dl	388 to <488 ng/dl	≥488 ng/dl
Age, baseline status adjusted	1.25 (0.92, 1.69)	1.57 (1.10, 2.24)	1.05 (0.77, 1.42)	1.00 (referent)	0.093
MV adjusted	1.09 (0.79, 1.51)	1.53 (1.06, 2.20)	1.04 (0.76, 1.43)	1.00 (referent)	0.409
Bioavailable T	<165.4 ng/dl	165.4 to <201.5 ng/dl	201.5 to <241.9 ng/dl	≥241.9 ng/dl
Age, baseline status adjusted	1.51 (1.10, 2.07)	1.29 (0.95, 1.76)	1.06 (0.78, 1.45)	1.00 (referent)	0.005
MV adjusted	1.32 (0.94, 1.84)	1.20 (0.87, 1.65)	0.97 (0.71, 1.33)	1.00 (referent)	0.055
SHBG	<35.7 nmol/liter	35.7 to <46.5 nmol/liter	46.5 to <59.3 nmol/liter	≥59.3 nmol/liter
Age, baseline status adjusted	1.10 (0.80, 1.51)	0.99 (0.73, 1.36)	1.18 (0.86, 1.60)	1.00 (referent)	0.846
MV adjusted	0.94 (0.67, 1.32)	0.98 (0.71, 1.36)	1.22 (0.89, 1.68)	1.00 (referent)	0.465

Multivariate (MV) models are adjusted for age, BMI, self-rated health, marital status, education, smoking, number of medical conditions, and baseline frailty status. Number of participants is 1245 for age-adjusted models for estradiol, total testosterone, and SHBG, and 1244 for multivariate models. T, Testosterone; E, estradiol.