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Illustrative LH (•) and T (○) concentration profiles in a 48-yr-old man administered ketoconazole (KTCZ) to block steroidogenesis, and then given four individual doses of T transdermally (zero, 2.5, 5.0, and 7.5 mg daily) on separate randomly ordered occasions. Blood was sampled every 10 min for 12 h.
