Table 4.

Effect of timing of LT₄ ingestion on the least squares means for thyroid analytes for all patients combined showing the P values for significant differences

Analyte	BB LT4 timing		WB LT4 timing		HS LT4 timing
	Mean	95% CI	Mean	95% CI	Mean	95% CI
Least squares TSH mean, mIU/liter	1.06	0.60–1.52	2.93	2.47–3.38	2.19	1.73–2.65
Difference from BB	n/a		See first column		See first column
Difference from WB	P < 0.001		n/a		See previous column
Difference from HS	P < 0.001		P = 0.026		n/a
Least squares FT4, mean ng/dl	1.35	1.31–1.39	1.24	1.20–1.28	1.34	1.30–1.38
Difference from BB	n/a		See first column		See first column
Difference from WB	P < 0.001		n/a		See previous column
Difference from HS	P = 0.72		P < 0.001		n/a
Least squares T3, mean ng/dl	128.7	124.1–133.4	123.4	118.7–128.0	125.5	120.8–130.1
Difference from BB	n/a		See first column		See first column
Difference from WB	P = 0.11		n/a		See previous column
Difference from HS	P = 0.33		P = 0.52		n/a

SI conversions: to convert FT₄ to picomoles per liter, multiply by 12.871; and to convert T₃ to nanomoles per liter, multiply by 0.0154.CI, Confidence interval; n/a, not applicable.