Table II.

18 biomarkers utilized for the discriminatory models between patients with vasculitis and controls (apparently healthy or patients with other chronic renal diseases)

Shown are the protein/peptide identification number in the data set (ID), mass (in Da), normalized migration time (CE-T; in min), the unadjusted (unadj) p values, p values adjusted using Bonferroni (Bonferroni) and Benjamini-Hochberg (BH), the AUC value in the ROC analysis (AUC), and the frequency and mean (median) amplitude based on data sets where the biomarker could be detected (omitting all 0 values) in the two groups of the training set, AAV and control (Contr). In addition sequence (lowercase p represents hydroxyproline), original protein, and the position of the first and last amino acids of the peptide in the respective protein sequence are given. Hemoglb, hemoglobin; Antitryp, antitrypsin; glycoprot, glycoprotein; Coll, collagen.

ID	Mass	CE-T	unadj p value	Bonferroni	BH	AUC	AAV	Mean (median)	Contr	Mean (median)	Sequence	Protein	Start	Stop
15800	1068.51	21.75	3.533920e−05	0.02887212	2.077131e−04	0.772	0.22	2.31 (2.52)	0.76	2.43 (2.47)	GEYKFQNAL	Serum albumin	423	431
25219	1213.61	27.2	9.220984e−07	0.000753354	1.295982e−05	0.880	0.83	3.24 (3.26)	0.13	2.53 (2.43)	VDEVGGEALGRL	Hemoglb β	21	32
30174	1292.59	28.28	1.697524e−05	0.01386877	1.185365e−04	0.797	0.78	2.48 (2.49)	0.15	2.78 (2.81)	TIDEKGTEAAGAM	α1-Antitryp	363	375
35339	1378.61	28.82	2.200089e−05	0.01797473	1.461360e−04	0.889	1	2.80 (2.81)	0.97	3.52 (3.55)	ApGEDGRpGPpGPQ	Coll α-1 (II)	511	524
38879	1439.66	29.82	1.009797e−06	0.000825004	1.309531e−05	0.825	0.94	3.06 (3.05)	0.6	2.61 (2.49)	TIDEKGTEAAGAMF	α1-Antitryp	363	376
40075	1448.78	20.27	8.613008e−07	0.000703682	1.256576e−05	0.876	0.83	3.53 (3.48)	0.14	2.90 (2.81)	VVAGVANALAHKYH	Hemoglb β	134	147
51120	1629.85	24.89	1.164354e−19	9.51277e−17	1.358967e−17	0.907	1	3.44 (3.62)	0.17	3.56 (3.59)	PMSIPPEVKFNKPF	α1-Antitryp	32	45
56033	1705.89	20.73	3.940837e−06	0.003219664	3.617600e−05	0.872	0.78	2.98 (3.01)	0.04	2.66 (2.71)	VLAHHFGKEFTPPVQ	Hemoglb β	114	128
60320	1797.93	23.9	3.645637e−06	0.002978485	3.423546e−05	0.867	0.78	4.70 (4.81)	0.1	3.48 (3.45)	WGKVNVDEVGGEALGRL	Hemoglb β	16	32
62557	1847.95	21.2	5.068519e−06	0.00414098	4.452667e−05	0.867	0.78	3.08 (3.22)	0.05	2.83 (2.81)	VLAHHFGKEFTPPVQAA	Hemoglb β	114	130
63772	1873.96	21.43	5.528687e−07	0.000451693	8.856740e−06	0.895	0.83	3.45 (3.52)	0.06	2.98 (2.96)	AAHLPAEFTPAVHASLDK	Hemoglb α	111	128
66483	1923.97	21.6	1.098620e−05	0.008975724	8.467664e−05	0.816	0.78	3.00 (2.97)	0.14	3.11 (2.98)	MGVVSLGSPSGEVSHPRKT	α2-HS-glycoprot	321	339
70633	2013.89	31.76	2.443416e−05	0.01996271	1.571867e−04	0.726	0.11	2.25 (2.25)	0.59	2.05 (2.06)	AGpPGPPGppGTSGHpGSpGSpG	Coll α-1 (III)	176	198
89325	2356.15	19.52	1.345930e−24	1.09962e−21	2.749062e−22	0.934	1	3.35 (3.35)	0.22	2.91 (2.91)	DAHKSEVAHRFKDLGEENFK	Serum albumin	25
90840	2389.24	22.4	7.466781e−10	0.00000061	3.050180e−08	0.860	0.94	4.40 (4.50)	0.3	3.85 (3.73)	MIEQNTKSPLFMGKVVNPTQK	α1-Antitryp	398
94543	2478.25	23.03	2.907457e−07	0.000237539	5.278650e−06	0.899	0.83	3.67 (3.69)	0.06	2.94 (2.69)	AAHLPAEFTPAVHASLDKFLASVS	Hemoglb α	111	134
98089	2559.18	19.41	8.924616e−06	0.007291412	7.079040e−05	0.845	0.89	3.78 (3.87)	0.44	2.88 (2.85)	DEAGSEADHEGTHSTKRGHAKSRP	Fibrinogen α	605	628
118597	3021.35	23.42	8.417339e−07	0.000687696	1.254231e−05	0.841	0.17	2.87 (2.92)	0.82	2.95 (3.03)	DGVSGGEGKGGSDGGGSHRKEGE EADAPGVIPG	CD99 antigen	97	129