Table 3.

Multivariable-adjusted regression of each inflammatory marker on brain MRI measure

	TCBV*100			Log-transformed WMH/TCV*100
	Estimate	95% CI	p Value	Estimate	95% CI	p Value
CD40L	0.11	−0.08, 0.30	0.25	−0.003	−0.07, 0.06	0.94
CRP	−0.25	−0.45,−0.05	0.02	−0.05	−0.012,0.03	0.21
s-ICAM-1	−0.17	−0.32,−0.02	0.03	0.05	−0.01, 0.10	0.09
IL-6	−0.26	−0.41,−0.10	0.001*	0.01	−0.04, 0.06	0.70
MCP-1	−0.01	−0.16, 0.13	0.86	−0.05	−0.10, 0.001	0.06
MPO	−0.15	−0.31, 0.005	0.06	−0.03	−0.08, 0.03	0.32
OPG	−0.30	−0.46, −.014	0.0003*	0.02	−0.03, 0.08	0.42
P-selectin	−0.19	−0.34,−0.03	0.02	−0.02	−0.07, 0.04	0.56
TNFr2	−0.15	−0.31, 0.005	0.06	0.01	−0.05, 0.06	0.81
TNF-α†	−0.36	−0.52,−0.20	<0.0001*	−0.03	−0.09, 0.02	0.26

Total n = 1,926; estimate = estimated average difference in MRI volume as log-transformed inflammatory marker increases from the 25th to the 75th percentile; 95% CI = 95% CI for change value. Models adjusted for age, sex, systolic blood pressure, diastolic blood pressure, body mass index, height, total/high density lipoprotein cholesterol, current smoking, fasting glucose, triglycerides, diabetes, hypertension treatment, hormone replacement therapy, lipid lowering treatment, aspirin, atrial fibrillation, electrocardiographic left ventricular hypertrophy, and prevalent cardiovascular disease.

^*Significant.

^†TNF-α data based on a participant subset (n = 1,430).

WMH = white matter hyperintensities; TCV = total cranial volume; CRP = C-reactive protein; sICAM-1 = soluble intracellular adhesion molecule-1; IL = interleukin; MCP-1 = monocyte chemoattractant protein-1; MPO = myeloperoxidase; OPG = osteoprotegerin; TNF = tumor necrosis factor.