Table 2.
Demographic and Neuropathological Characteristics of Subjects Examined at Autopsy
| Characteristic | No GBA Mutation (n=153) |
GBA Mutation (n=34) |
P Value |
|---|---|---|---|
| Sex, No. (%) male | 79 (52) | 21 (62) | .34 |
| Ethnicity, No. (%) | .26 | ||
| White | 123(80) | 32 (94) | |
| Black | 7(5) | 0 | |
| Asian | 2(1) | 0 | |
| Hispanic | 21 (14) | 2(6) | |
| Age at death, mean (SD),y (n = 187) | 77.8(11) | 76.0(6.7) | .21 |
| Age at dementia (total), mean (SD),y (n = 113) | 69.1 (10) | 63.2 (6.7) | .01 |
| Duration from onset of dementia or parkinsonism to death, mean (SD), y (n = 113) | 10.0(6) | 12.6(5.8) | .07 |
| No. (%) with Lewy bodies | |||
| Any | 79 (52) | 29(85) | <.001 |
| Cortical | 66 (43) | 28(82) | <.001 |
| Subcortical | 13(8) | 1(3) | .24 |
| No. (%) with pathological findings of AD | |||
| Any | 123(80) | 29(85) | .35 |
| Diagnosis (NIA-RI) | 96 (63) | 13(38) | .01 |
Abbreviations: AD, Alzheimer disease; NIA-RI, National Institute on Aging–Reagan Institute.