Table 4.
Association of GBA Mutation With the Presence of Cortical Lewy Bodies or AD Pathological Diagnosis
OR (95% CI) | P Value | Covariates in Model |
---|---|---|
Cortical Lewy Bodies | ||
7.24(2.69–19.48) | <.001 | Age at death, sex, AD pathological diagnosis |
6.62(2.41–18.27) | <.001 | Age at death, sex, any AD pathological findings |
6.48(2.45–17.16) | <.001 | Age at death, sex, APOE4 |
5.91 (2.14–16.33) | <.001 | Age at death, sex, APOE4, dementia |
AD Pathological Diagnosis | ||
0.40(0.18–0.89) | .03 | Age at death, sex |
0.35(0.15–0.79) | .01 | Age at death, sex, APOE4 (for AP0E4 OR, 3.97; 95% CI, 1.97–8.04; P< .001) |
Abbreviations: AD, Alzheimer disease; CI, confidence interval; OR, odds ratio.