Table 1.

Protein	Core TM sequence	Calculated hydrophobicity*	Predicted ΔG‡
Synaptobrevin 2	MMIILGVICAIILIIIIVYF	64	–3.80
RAMP4	GPWLLALFIFVVCGSAIFQII	41	–1.27
Cytochrome b5	WTNWVIPAISAVAVALMYRLYM	25	+0.20

^*(Kalbfleisch et al., 2007)

^‡The predicted ΔG provides an alternative indication of biological hydrophobicity (Hessa et al., 2007). The more negative the value, the more hydrophobic the TM segment shown