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. 2009 Oct 7;106(42):17864–17869. doi: 10.1073/pnas.0904174106

Fig. 4.

Fig. 4.

Unlike intact IgGs, single-cleaved IgGs that target in vivo cells do not cause cell clearance. (A) Percentage of remaining murine CD4+ splenocytes detected in vivo by flow cytometry at 4 days following treatment with no antibody (control), intact GK1.5, and single-cleaved GK1.5 (scIgG). Bar heights correspond to the mean ± SD of five animals. (B) Blood platelet counts in dogs before and 24 h after treatment with no antibody (control), intact mAb3, and single-cleaved mAb3. Bar heights correspond to the mean ± SD of five animals.