Table 3.
Studies evaluating VHA in trauma patients
| Author | No. | ISS | Study type | Major conclusions | Ref. |
|---|---|---|---|---|---|
| Kaufman (1997) | 69 | 13/29 | RS | Moderately injured patients (ISS 13) were hypercoagulable whereas severely injured (ISS 29) patients were hypocoagulable according to VHA | [51] |
| Schreiber (2005) | 65 | 23 | RS | 62% of the patients where hypercoagulable 1st day of trauma according to VHA which is more sensitive to identify this state than RCoT. | [52] |
| Rugeri (2007) | 90 | 22 | PO | VHA rapidly detects systemic changes of in vivo coagulation in trauma patients, and it might be a helpful device in guiding transfusion. | [76] |
| Plotkin (2008) | 44 | 21 | RS | VHA is a more accurate indicator of transfusion requirements than PT, APTT and INR | [77] |
| Levrat (2008) | 87 | 20/75 | PO | VHA provides rapid and accurate detection of hyperfibrinolysis in severely injured trauma patients | [78] |
| Schöchl (2009) | 33 | 47 | PO | VHA based diagnosis of hyperfibrinolysis predicted outcome in severely injured trauma patients | [79] |
| Carroll (2009) | 161 | 20 | PO | Abnormal VHA parameters correlated with fatality. Coagulopathy as evaluated by VHA was present already on the scene of accident. | [80] |
| Jaeger (2009) | 20 | ?? | RS | RapidTEG provides earlier detection of coagulopathy than standard VHA and RCoT | [81] |
| Park (2009) | 78 | 20 | PO | VHA detected hypercoagulability and this was not seen with RCoT in trauma patients | [82] |
| Kashuk (2009) | 44 | 29 | RS | RapidTEG may effectively guide transfusion therapy in trauma patients | [83] |
RCoT = routine coagulation tests, RS = Retrospective study, PO = Prospective observational study