Table 5.
Equations used to predict GI50 values for DNA-binding drugsa.
| Predictive equation | r | p | AdR2 | |
| All drugsc | GI50 = 0.002(± 0.001)Complexity - 0.008(± 0.004)PSA + 5.688(± 0.591) | 0.713 | 1.4 × 10-2 | 0.426 |
| Intercalators | GI50 = 0.742(± 0.219)logKeq + 0.002(± 0.000)Complexity + 0.008(± 0.002)PSA + 1.977(± 1.319) | 0.894 | 1.6 × 10-2 | 0.700 |
| 'M-region' | GI50 = 0.021(± 0.102)logKeq + 0.001(± 0.000)Complexity + 6.478(± 0.746) | 0.984 | 1.8 × 10-4 | 0.955 |
The predictive equations are presented for the three sets of drugs analyzed (All 15 drugs, Intercalators and 'M-region' compounds) described in the main textb.
a Obtained by multiple regression analysis. The predictive equations displayed are those statistically more significant for each set of predictors (actual p values, ANOVA test, are shown in the Table). Other details as in legend to Table 4.
bThe cases (drugs) used in the calculations for each set were 15, 10 and 8 respectively.
clogKeq was not a significant predictor for GI50 for the set that contains the 15 (all) drugs.