Table 2.
Top 10 significantly over-represented Pfam domains in cancer genes vs. non-cancer genes
| ID | # cancer genes | # non-cancer genes | Chi-square | p-value | Name | Description |
| PF07714 | 25 | 21 | 245.2 | 2.88E-55 | Pkinase_Tyr | Protein tyrosine kinase |
| PF00069 | 31 | 54 | 188.2 | 8.03E-43 | Pkinase | Protein kinase domain |
| PF00178 | 7 | 0 | 122.1 | 2.17E-28 | Ets | Ets-domain |
| PF00292 | 4 | 0 | 61.5 | 4.36E-15 | PAX | 'Paired box' domain |
| PF00270 | 7 | 10 | 43.0 | 5.42E-11 | DEAD | DEAD/DEAH box helicase |
| PF01119 | 3 | 0 | 41.6 | 1.11E-10 | DNA_mis_repair | DNA mismatch repair protein, C-terminal domain |
| PF02518 | 5 | 4 | 41.5 | 1.18E-10 | HATPase_c | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase |
| PF00017 | 9 | 20 | 39.6 | 3.08E-10 | SH2 | SH2 domain |
| PF00855 | 5 | 5 | 36.5 | 1.53E-09 | PWWP | PWWP domain |
| PF00046 | 17 | 90 | 28.2 | 1.11E-07 | Homeobox | Homeobox domain |