Table 2.
Bortezomib and vorinostat CTC-version 3 toxicities for cycles 1 and cumulative for cycles 2–8.
| Toxicity | Cycle 1 | Cycle 2–8 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No | Grade | No | Grade | |||||||
| 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | |||
| Anemia | 7 | 2 | 4 | 1 | - | 16 | 4 | 7 | 3 | 2 |
| Neutropenia | 4 | 2 | - | 2 | - | 7 | 1 | 3 | 3 | - |
| Platelets | 12 | 3 | 3 | 3 | 3 | 17 | 3 | 1 | 7 | 6 |
| Diarrhea | 12 | 9 | 1 | 2 | - | 11 | 8 | 1 | 2 | - |
| Nausea | 11 | 9 | 1 | 1 | - | 12 | 6 | 6 | - | - |
| Vomiting | 5 | 2 | 2 | 1 | - | 7 | 4 | 2 | 1 | - |
| Constipation | 1 | 1 | - | - | - | 3 | 3 | - | - | - |
| Fatigue | 8 | 4 | 3 | 1 | - | 11 | 2 | 4 | 5 | - |
| Fever | 5 | 2 | 2 | 1 | - | 4 | 3 | 1 | - | - |
| Peripheral neuropathy |
13 | 11 | 2 | - | - | 14 | 5 | 9 | 1 | - |
| Dyspnea | 0 | - | - | - | - | 5 | 1 | 1 | 3 | - |
| Hypotension | 0 | - | - | - | - | 5 | 3 | 1 | 1 | - |
| Atrial fib. | 0 | - | - | - | - | 1 | - | 1 | - | - |
| Prolonged QTC | 10 | 7 | 2 | 1 | - | 0 | - | - | - | - |
| Pneumonia | 0 | - | - | - | - | 3 | - | - | 3 | - |
| Shingles | 0 | - | - | - | - | 2 | - | 2 | - | - |
| Creatinine | 7 | 2 | 5 | - | - | 8 | 4 | 3 | 1 | - |
| Hyponatremia | 6 | 5 | 1 | - | - | 10 | 6 | - | 4 | - |
| Hypokalemia | 2 | - | - | 2 | - | 5 | 3 | - | 2 | - |
| Hypocalcemia | 1 | 1 | - | - | - | 5 | 2 | 2 | 1 | - |
| LDH | 5 | 3 | 2 | - | - | 4 | 4 | - | - | - |
| AST | 4 | 3 | 1 | - | - | 5 | 4 | - | 1 | - |
| ALT | 3 | 3 | - | - | - | 2 | - | 2 | - | - |