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. Author manuscript; available in PMC: 2010 Oct 14.
Published in final edited form as: J Am Chem Soc. 2009 Oct 14;131(40):14231–14233. doi: 10.1021/ja9061823

Table 2.

Phosphine-catalyzed asymmetric γ additions of nitromethane to allenamides.

graphic file with name nihms147483u4.jpg
entry R ee (%) yield (%)a
1 Me 97 94
2 n-Pr 93 81
3 graphic file with name nihms147483t1.jpg 87 73
4b i-Pr 81 62
5 (CH2)4OTBS 92 57
6 (CH2)3CO2Me 93 75
7 (CH2)5CO2Me 92 82
8 graphic file with name nihms147483t2.jpg 92 83
9 graphic file with name nihms147483t3.jpg 93 84

All data are the average of two experiments.

a

Yield of purified product.

b

15% 1 was used.