Figure 3. Mapping of the GLI3-protein region critical for it's MID1-PP2A-dependent regulation.
Left: Schematic representation of the functional domains of GLI3 and the deletion constructs used in this study. Right: Effects of MID1- or α4-knockdown on the nuclear localization of the respective GLI3-deletion-construct. A significant decrease of nuclear GLI3 is indicated by +.