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. 2009 Oct 16;4(10):e7487. doi: 10.1371/journal.pone.0007487

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Salimpoor et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Real-time physiological recordings plotted against the time-course of the chills response reveal that chills are experienced during the peak of sympathetic nervous system activity. Individuals who experienced no pleasure to the same excerpts did not show significant changes in psychophysiological responses during the epochs that chills were experienced in individuals who found the music highly pleasurable.