Fig. 3.

Functional and frequency analysis of regulatory T cells of relapsing–remitting multiple sclerosis (RR-MS) before and after glucocorticoid (GC) treatment. (a) Suppression of carboxyl fluorescein diacetate succinimidyl ester (CFSE)-labelled responder cells from healthy controls (HC) by bead-sorted CD4⁺CD25⁺ T cells from HC and MS patients. CFSE histograms from one representative HC and RR-MS patient are shown. (b) Frequencies of CD4⁺CD25⁺forkhead box P3 (FoxP3)⁺ T cells in the peripheral blood of HC, RR-MS and secondary-progressive MS (SP-MS) patients. (c) Frequencies of regulatory T cells with interleukin (IL)-10 secretion.