Table 3.

Haplotype A, B and K association P values (individual and global) and case–control frequencies for the MI, EOCAD and AORTA phenotypes; results for MI and EOCAD are presented overall and stratified by race; expression tags for ALOX5, ALOX5AP and LTA4H were analyzed as a continuous variable

Haplotype	Phenotype	Race	Haplotype frequency		P value	Global P value
			Control	Case
ALOX5AP HapA	MI	All	0.12	0.14	0.11	0.75
		AA	0.11	0.09	0.33	0.48
		CA	0.12	0.15	0.07	0.48
	EOCAD	All	0.12	0.15	0.02	0.45
		AA	0.11	0.08	0.67	0.78
		CA	0.12	0.17	0.01	0.25
	Raised lesion	All	0.18	0.20	0.06	0.40
	Sudan IV		0.21	0.17	0.11	0.08
	307_AT (ALOX5)		NAa		0.06	0.97
	33153_AT (ALOX5)				0.31	0.55
	37099_at (ALOX5AP)				0.03	0.23
	38081_at (LTA4H)				0.16	0.77
ALOX5AP HapB	MI	All	0.08	0.09	0.64	1.00
		AA	0.14	0.14	0.87	0.80
		CA	0.06	0.08	0.61	0.0001
	EOCAD	All	0.08	0.10	0.39	0.72
		AA	0.14	0.16	0.37	0.89
		CA	0.06	0.08	0.44	0.65
	Raised lesion	All	0.08	0.07	0.76	0.00001
	Sudan IV		0.09		0.58	0.04
	307_AT (ALOX5)		NAa		0.38	0.11
	33153_AT (ALOX5)				0.41	0.08
	37099_at (ALOX5AP)				0.24	0.21
	38081_at (LTA4H)				0.18	0.37
LTA4H HapK	MI	All	0.12	0.14	0.57	0.07
		AA	0.08	0.07	0.63	0.16
		CA	0.14	0.15	0.79	0.83
	EOCAD	All	0.12	0.13	0.04	0.33
		AA	0.07	0.05	0.27	0.62
		CA	0.14	0.16	0.03	0.54
	Raised lesion	All	0.19	0.10	0.32	0.06
	Sudan IV		0.18	0.17	0.71	0.02
	307_AT (ALOX5)		NAa		0.41	0.18
	33153_AT (ALOX5)				0.16	0.07
	37099_at (ALOX5AP)				0.94	0.13
	38081_at (LTA4H)				0.27	0.0009

Two statistical tests were performed, one comparing the frequency of the particular haplotype of interest in cases and controls and the second performing the global test of haplotype association testing the null hypothesis that there were no haplotype differences between cases and controls. The alternative hypothesis was that at least one of the haplotypes (not necessarily the haplotype of interest) was different

^aExpression values analyzed as a continuous variable

P values ≤0.05 are shown in bold