Table 3.
The role of explanatory factors in explaining the link between IMT and cognition in the low SES group.†
| beta‡ (95% CI) | p | %Δ# | ||
|---|---|---|---|---|
| AH4-I | ||||
| IMT (adjusted for age & sex) | −.144 (−.232, −.057) | 0.001 | ||
| + CHD | −.135 (−.223, −.048) | 0.003 | 6.3% | |
| + SBP, DBP, Cholesterol, BMI | −.125 (−.215, −.035) | 0.006 | 13.2% | |
| + alcohol, smoking | −.133 (−.219, −.047) | 0.003 | 7.6% | |
| + all above | −.107 (−.196, −.018) | 0.02 | 25.7% | |
|
| ||||
| Mill Hill | ||||
| IMT (adjusted for age & sex) | −.144 (−.232, −.055) | 0.002 | ||
| + CHD | −.128 (−.217, −.040) | 0.005 | 11.1% | |
| + SBP, DBP, Cholesterol, BMI | −.136 (−.226, −.045) | 0.003 | 5.6% | |
| + alcohol, smoking | −.123 (−.210, −.037) | 0.005 | 14.6% | |
| + all above | −.104 (−.193, −.015) | 0.02 | 27.8% | |
|
| ||||
| Phonemic fluency | ||||
| IMT (adjusted for age & sex) | −.121 (−.208, −.034) | 0.006 | ||
| + CHD | −.114 (−.201, −.027) | 0.01 | 5.8% | |
| + SBP, DBP, Cholesterol, BMI | −.113 (−.203, −.024) | 0.01 | 6.6% | |
| + alcohol, smoking | −.110 (−.196, −.023) | 0.01 | 2.5% | |
| + all above | −.096 (−.186, −.006) | 0.04 | 20.7% | |
|
| ||||
| Semantic fluency | ||||
| IMT (adjusted for age & sex) | −.106 (−.193, −.020) | 0.02 | ||
| + CHD | −.105 (−.192, −.018) | 0.02 | 1.0% | |
| + SBP, DBP, Cholesterol, BMI | −.082 (−.171, .006) | 0.07 | 22.6% | |
| + alcohol, smoking | −.095 (−.180, −.010) | 0.03 | 10.4% | |
| + all above | −.071 (−.159, .016) | 0.11 | 33.0% | |
†
Analysis restricted to those with complete data and the “low” SES group.
‡
Standardized regression coefficient
#
Percentage reduction in the regression coefficient = (betaIMT, controlling for age − betaIMT, controlling for age and covariate)/(betaIMT, controlling for age)×100.