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. Author manuscript; available in PMC: 2009 Oct 8.
Published in final edited form as: J Am Chem Soc. 2008 Mar 25;130(15):5178–5184. doi: 10.1021/ja710159q

Figure 4.

Figure 4

MTRasy at 1 ppm measured with respect to the presaturation time Tsat for the three liposome sizes each containing 200 mM TmDOTA. The data are analyzed by three methods: (a) method (i), using eqs 5 and 6 to fit for kwl and α and obtaining T1w from the fitted value of kwl; (b) method (ii), using eqs 5 and 7 to fit for kwl and T1w and obtaining α from these fitted values; (c) method (iii), fitting for kwl and T1w by numerically solving Bloch equations and obtaining α from these fitted values. (d) Linear regression analyses of the exchange rates from method (i) (•, dashed line), method (ii) (■, dotted line), method (iii) (▲, solid line) versus the total surface areas per volume. The slope represents the permeability of liposomal membrane according to eq 4.