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Schematic illustration of signaling pathway mediated by α1(IV)NC1. α1(IV)NC1 binds to α1β1 integrin and cross talk with growth factor receptors, and inhibit phosphorylation of FAK. Inhibition of FAK activation leads to inhibition of Raf/MEK/ERK1/2/p38 MAP kinase pathways that leads to inhibition of HIF-1α and VEGF expression which in turn results in inhibition of endothelial cell migration, proliferation and tube formation in proliferating endothelial cells.
