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Schematic illustration of different signaling pathway mediated by α3(IV)NC1. α3(IV)NC1 binds to αVβ3 and α3β1 integrins, and inhibits phosphorylation of FAK. Inhibition of FAK activation leads to inhibition of FAK/PI-3K/eIF4E/4E-BP1 cap dependent translation. In addition α3(IV)NC1 inhibits NFκB mediated signaling in hypoxic conditions leading to inhibition of COX-2/VEGF/bFGF expression, resulting in inhibition of hypoxic tumor angiogenesis.
