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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Neurotoxicology. 2009 Feb 13;30(3):436–444. doi: 10.1016/j.neuro.2009.02.003

Figure 4.

Figure 4

Interactions of AP4A and MA in the first 10-min exploratory phase of locomotor activity. Locomotor parameters were monitored at one day after systemic MA or saline injection in adult rats. In animals receiving i.c.v. vehicle pretreatment, MA dose-dependently reduced (A) movement number, (B) vertical activity, (C) horizontal movement time, and (D) vertical movement time. Pretreatment with AP4A significantly enhanced movement number, vertical activity and vertical movement in MA –treated rats. A marginal increase in horizontal movement time was found in animals treated with AP4A (p=0.078, 2-way ANOVA).