Figure 1.

Space filling model of HbA CO (25), with a view of the α₁β₂ interface in two orthogonal projections. α and β chains, colored in light blue, are respectively at the upper left and lower right of the left view. Amino acids belonging to the interface are indicated following their atom specification, i.e., C in green, O in red, and N in deep blue. Residues mutated in this work are labeled with their names. Hemes are not highlighted.