. Author manuscript; available in PMC: 2010 Jul 15.

Published in final edited form as: Bioorg Med Chem. 2009 Jun 22;17(14):5027–5037. doi: 10.1016/j.bmc.2009.05.070

Table 3. Results of VIM-2 inhibitor MIC and inhibitor plus imipenem MIC potentiation assays.

All experiments were repeated at least on three different days and MIC values were determined as per CLSI guidelines (11). The E. coli strain ATCC 25922 was used as a quality control reference.

Compound Name	Compound MIC (μg/mL)		Imipenem MIC @ 50 μM of compound, μg/mL
Compound Name	BL21	BL21+VIM-2	BL21+VIM-2
Mitoxantrone	8.4	8.4	0.2
pCMB	17.9	17.9	0.2
1	> 60	> 60	1.9
2	> 60	> 60	1.9
Imipenem	0.2	1.9	-