Table 4. Activity of Imipenem in Combination with pCMB and Mitoxantrone vs. BL21/VIM2 E. coli.

Results obtained from checkerboard microdilution experiment. Shaded values are combination of Imipenem and inhibitor that were found to be synergistic.

	Imipenem + pCMB		Imipenem + Mitoxantrone
	Imipenem MIC, μg/mL	p-CMB, μg/mL	Imipenem MIC, μg/mL	Mitoxantrone, μg/mL
MIC of Imipenem in Presence of Inhibitor, μg/mL	<0.1	35.8	<0.1	66.9
	<0.1	17.9	<0.1	33.5
	0.1	8.9	<0.1	16.7
	0.1	4.5	<0.1	8.4
	0.5	2.2	0.2	4.2
	0.9	1.1	0.5	2.1
	1.9	0.6	0.5	1.0
	1.9	0.3	1.9	0.5
	1.9	0.1	1.9	0.3
MIC alone, μg/mL	1.9	17.9	1.9	8.4