Table 1. Behavioral effects of a chronic fluoxetine treatment in the chronic corticosterone paradigm and the β-arrestin 2 KO mice.
Summary of effects seen in multiple behavioral tests throughout the study. ↓ decrease parameter; ↑ increase parameter; 0 no effect; Vehicle1: versus vehicle-treated group; Chronic Fluoxetine2: versus chronic corticosterone-treated group; Vehicle3: versus vehicle-treated wild type littermate; Chronic Fluoxetine4: versus vehicle-treated β-arrestin KO mice
| Open Field | Light Dark | Elevated plus Maze |
Novelty Suppressed Feeding |
Splash Test |
Forced Swim Test |
Tail Suspension Test |
||
|---|---|---|---|---|---|---|---|---|
| Time in the center |
Entries into the light |
Time in Open arms |
Latency to Feed |
Grooming frequency |
Mobility duration |
Mobility duration |
||
| Chronic Corticosterone paradigm | Vehicle1 | ↓ | Not tested | Not tested | ↑ | ↓ | 0 | Not tested |
| Chronic Fluoxetine2 | ↑ | Not tested | ↑ | ↓ | ↑ | ↑ | ↑ | |
| βarrestin 2 KO mice | Vehicle3 | ↓ | 0 | Not tested | ↑ | 0 | 0 | ↑ |
| Chronic Fluoxetine4 | 0 | 0 | Not tested | 0 | 0 | ↑ | 0 |
Legend: ↓decrease parameter; ↑ increase parameter; 0 no effect; Vehicle1: versus vehicle-treated group; Chronic Fluoxetine2: versus chronic corticosterone-treated group; Vehicle3: versus vehicle-treated wild type littermate; Chronic Fluoxetine4: versus vehicle-treated β-arrestin KO mice