Table 2.

Number of PMS2 mutation carriers by age at diagnosis and family history in probands with isolated loss of PMS2 in their tumor by IHC.

	Total	PMS2 mutation carrier (%)
Age <50	47	27 (57.4)
and affected FDR and/or SDR	27	17 (63)
Age >50	46	28 (60.9)
and affected FDR and/or SDR	26	15 (57.7)

FDR = first degree relative, SDR = second degree relative. Probands were considered mutation positive only when a deleterious mutation was identified. Patients with uncertain missense variants were considered negative. Biallelic mutation carriers (n=6) were excluded from this table.