Table 6.

Penetrance as hazard ratio and risk to age 70 for cancer based on sex for North America, Australia, and Sweden.

Cancer	Sex	Hazard ratio (95% CI)	Cumulative risk (95% CI)
			to age 50	to age 60	to age 70
Colorectal	Male	5.2 (2.8–9.7)	2% (1%–4%)	8% (4%–14%)	20% (11% – 34%)
	Female	5.2 (2.8–9.7)	2% (1%–4%)	6% (3%–10%)	15% (8% – 26%)
Endometrial	Female	7.5 (2.8–20.0)	3% (1%–8%)	9% (3%–21%)	15% (6% – 35%)
Less frequent Lynch cancers*	Male	2.5 (0.4–16.2)	1% (0%–8%)	3% (0%–17%)	6% (1% – 33%)
	Female	2.5 (0.5–12.6)	1% (0%–7%)	3% (1%–13%)	6% (1% – 25%)
Other cancers	Male	0.9 (0.3–2.3)	4% (1%–9%)	10% (4%–24%)	24% (10% – 51%)
	Female	1.5 (0.8–3.1)	8% (4%–15%)	16% (8%–29%)	27% (15% – 48%)
Any Lynch Syndrome-associated cancer	Male		4% (2%–10%)	10% (6%–24%)	25% (16%–48%)
	Female		6% (4%–14%)	16% (10%–31%)	32% (21%–53%)

^*Kidney (renal pelvis), stomach, ovary, small bowel, ureter, brain