Table II.

Advantages and disadvantages of heterotopic and orthotopic sites for ovarian tissue transplantation

	Heterotopic site (subcutaneous)	Orthotopic site
Advantages	No limitation of the number of fragments transplanted	Possibility of natural conception
	Easy transplantation procedure	Restoration of fertility demonstrated
	Easy access for follicular monitoring and oocytes collection	Favourable environment for follicular development
Disadvantages	Restoration of fertility not yet demonstrated	Number of fragments transplanted limited by the ovarian size
	IVF procedure required	Invasive transplantation procedure
	Effect of the local environment on the oocyte quality is unknown