Table IV.
Follow-up of the follicular development after cryopreserved ovarian tissue transplantation in order to restore fertility of a patient with premature ovarian failure after bone marrow transplantation
| Days post-transplantation | Cycle | Foll. phase length | bFSH | Follicles size at ovulation (mm) |
Post-ovulation decision |
Results | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ovary | Peritoneal | SC right | SC left | Oocytes collected | Fertilization (IVF) | Embryo transfer | |||||
| Nov 2004 (0) | First transplantation (ovary-SC right- peritoneal sites) | ||||||||||
| 148 | Spontaneous | 22 | 12–12.5 | 21 | 13.5 | Timing intercourse | No pregnancy | ||||
| 165 | Spontaneous | 5 | 7 | 16.5–10–8 | 8 | – | Timing intercourse | No pregnancy | |||
| 190 | Spontaneous | 11 | 5 | ND | ND | ND | Timing intercourse | No pregnancy | |||
| 213 | Spontaneous | 10 | 6 | 16–14–13 | – | – | Timing intercourse | No pregnancy | |||
| 237 | Spontaneous | 12 | 6 | 15–11.5 | – | 11 | Timing intercourse | No pregnancy | |||
| 261 | Spontaneous | 11 | 9 | 19.5–10 | – | 10 | Timing intercourse | Miscarriage | |||
| 372 | Spontaneous | 21 | 19 | 18–14 | – | 12 | Timing intercourse | No pregnancy | |||
| 389–409 | Pill | – | 41 | OC 34 | – | – | – | No pregnancy | |||
| 434 | Stimulation | – | – | 18 | – | – | Timing intercourse | No pregnancy | |||
| 518 | Spontaneous | 28 | 19 | 17.5–11.5 | – | 16–11 | 2 | 1 (SC site) | 1 (3 cells) | No pregnancy | |
| May 2006 | Second transplantation (ovary-SC left sites) | ||||||||||
| 583 | Spontaneous | 17 | 25 | – | – | 16.5–10.5 | – | 1 | 0 (deg) | 0 | No pregnancy |
| 608 | Spontaneous | 11 | 24 | – | – | 15 | – | Timing intercourse | No pregnancy | ||
| 635 | Spontaneous | 11 | 6 | 11 | – | 17.5–13 | – | 1 | 0 (deg) | 0 | No pregnancy |
| 650 | Spontaneous | 7 | 6 | 22.5 | – | – | – | Timing intercourse | No pregnancy | ||
| 669 | Spontaneous | 9 | 9 | 15–15 | – | – | – | Timing intercourse | Pregnancy | ||
| June 2007 | Delivery of healthy girl | ||||||||||
| PP-3 months | Spontaneous | 2 follicles | – | – | – | – | – | ||||
| PP-4 months | Spontaneous | ND | ND | – | – | – | – | ||||
| PP-5 months | Spontaneous | 6 | 17.5 | – | 19–14.5 | 12.5 | 0 | 0 | 0 | – | |
| PP-8 months | Spontaneous | 26 | ND | ND | – | – | – | ||||
| PP-15 months | Spontaneous | 17.3 | ND | ND | |||||||
| PP-17 months | Spontaneous | 45 | ND | ND | |||||||
Transplantation procedure has been performed twice in November 2004 and in May 2006 at different sites: ovarian, sub-cutaneous and/or peritoneal. Follicular phase length, basal FSH levels (bFSH), the follicular site at the time of ovulation and the outcomes of each cycle are reported.
deg = degenerated; ND = not done; OC = ovarian cyst; SC = sub-cutaneous, PP = post-partum.