Table 9.

Summary of multi-category, multi-analyte detection methods and their LODs.

Analytes	Experiment Type	Method	Sampling technique (if applicable)	LOD	Reference
21 compounds related to metabolism of Tyr, Trp, and Glu	Method Development	LC/MS/MS		0.1 – 100 nM	[299]
DA or Glu	Method Development	Biosensor — voltammetry		100 μM*	[304]
Glu, DA	Method development	CE-EC w/in capillary enzyme rxn	microdialysis	Glu: 4 mM DA: 3 mM*	[300]
Glu, GABA, DA, 5HT	Method development w/testing of ex vivo tissue samples following organism manipulation	LC/FLD/MS		Glu: 0.687 nM GABA: 0.799 nM DA: 1.258 nM 5HT: 0.398 nM	[301]
NO or DA	Method development	Biosensor—amperometry		NO:< 50 nM DA: 10 nM*	[305]
ACh, 5HT, DA, GABA, Glu, Asp	Method development w/testing in vivo	LC/MS	LFPP	ACh: 0.05 nM 5HT: 0.5 nM DA: 1 nM GABA: 4 nM Glu: 20 nM Asp: 50 nM	[302]
Glu, ACh, DA	Method development with in vivo testing	FIA w/triple biosensor detection—amperometry	microdialysis	1.5 μM	[303]

^*indicates lowest detected concentration.