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. 2009 Mar 10;100(6):1128–1136. doi: 10.1111/j.1349-7006.2009.01150.x

Figure 4.

Figure 4

RO‐3306 downregulates the expression of antiapoptotic Bcl‐2 and survivin and blocks p53‐mediated induction of murine double minute 2 homolog (MDM2) and p21. (a) Protein expression in MOLM‐13 cells, which were treated for up to 6 h with 5 µM RO‐3306 or 2.5 µM Nutlin‐3 either as individual agents or in combination. β‐Actin was used to confirm equal loading of proteins. (b) Protein expression in OCI‐AML‐3 and HL‐60 cells, which were treated for 6 h with RO‐3306 (5 µM) or Nutlin‐3 (5 µM in OCI‐AML‐3 and 2.5 µM in HL‐60) either as individual agents or in combination. β‐Actin was used to confirm equal loading of proteins. Results are representative of three independent experiments.