. Author manuscript; available in PMC: 2010 Jul 15.

Published in final edited form as: Bioorg Med Chem. 2009 Jun 2;17(14):5044–5053. doi: 10.1016/j.bmc.2009.05.065

Table 1.

Flexidock Score for molecules 9a–f with COX-2 and μ opiate receptor

Compound	FlexiDock scores with COX-2	Compound	FlexiDock scores with opiate μ-receptor

Indomethacin	− 101.7	Fentanyl	− 25.0
Compound 9a	− 95.3	Compound 9a	− 79.0
Compound 9b	− 116.1	Compound 9b	− 57.0
Compound 9c	− 110.9	Compound 9c	− 36.0
Compound 9d	− 100.0	Compound 9d	− 67.0
Compound 9e	− 117.3	Compound 9e	− 68.0
Compound 9f	− 113.4	Compound 9f	− 77.0