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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Nat Med. 2009 Aug 23;15(10):1208–1214. doi: 10.1038/nm.2019

Figure 2.

Figure 2

LGI1 down-regulates postsynaptic NR2B-dependent NMDA receptor currents during postnatal brain development. (a,b) Representative current traces from wild-type (WT) showing NR2B subunit-dependent current is larger in immature (a) than mature (b) wild-type GCs. Ro: NR2B blocker; PPDA: NR2C/2D blocker. (c,d) Representative current traces showing NR2B-dependent currents remain high in mature mLGI1 (c) and down-regulate excessively in mature LGI1 OE (d) transgenic mice relative to mature wild-type (b). (e) Representative traces showing Src kinase inhibitor, PP2, inhibits the NR2B component in mature mLGI1. (f) Quantification of NR2B/NR2A* current ratio in the three genotypes (n = 5 to 11) across postnatal development in the presence and absence of PP2. *: P < 0.05; **: P < 0.01.

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