Table 1.
Topics in standardization that are discussed in synthetic biology (based on http://bbf.openwetware.org/Standards/Technical.html and Canton et al. 2008)
Topic | Features |
---|---|
Standardized DNA formats | Standard cloning sites for facilitated physical assembly of parts and devices (DNA, RNA, proteins) and for DNA synthesis and construction |
Data exchange standards | Information on unique ID, DNA sequence/sequence of basic building blocks, the format (specifying: prefix, suffix, scar, name, description), short/long description for humans, target chassis, experience record (e.g., works in… chassis, in the hands of…), source genebank ID if applicable, source organism, source lab/person, references (web/literature) |
Standardized comprehensive datasheet of parts or devices | Summary of current knowledge of a specific part with information on mechanism and function, static performance, dynamic performance, input compatibility, reliability, part compatibility, ontology etc. |
Measurement standards | Standard experimental design to determine, e.g., promoter strengths, RBS |
Chassis standards | Standard strains and chassis characterization |
Reporting standards | Defined vocabulary, systematic references for data mining |
Coordination with other standard setting organizations | Common platform to exchange ideas, linkage between the “worlds” (biological, electronical, computer science) |