Table 6.
Responsiveness indices: declined and unchanged groups based on “On a scale of 1 to 10, where 10 is best possible quality of life and 1 is the worst possible quality of life (as bad or worse than being dead) overall, how would you rate your quality of life?”a
| Baseline mean in declined group (SD) | Average change in declined group (SD) | Average change in the unchanged group (SD) | Effect size statistic | SRM | Guyatt | F (P value) | |
|---|---|---|---|---|---|---|---|
| SF-36 v. 1.0 (range: 0–100, where 100 is best quality of life) | |||||||
| Physical Function | 59.1 (29.2) | −12.6 (23.9) | −7.0 (24.3) | −0.43d | −0.53 | −0.52 | 0.58 (0.45) |
| Role Limitations—Physical | 50.0 (44.7) | −15.6 (49.1) | 4.5 (33.5) | −0.35d | −0.31 | −0.47 | 2.94 (0.09) |
| Role Limitations—Emotional | 93.8 (25.0) | −12.5 (29.5) | −7.6 (51.2) | −0.50c | −0.42 | −0.24 | 0.13 (0.72) |
| Pain | 69.8 (23.3) | −9.5 (32.8) | 8.9 (29.7) | −0.40d | −0.29 | −0.32 | 3.95 (0.05) |
| Emotional Well-Being | 80.5 (7.4) | −6.0 (19.3) | 0.9 (16.4) | −0.81b | −0.31 | −0.37 | 1.75 (0.19) |
| Energy | 60.6 (20.4) | −17.2 (24.2) | −4.7 (24.7) | −0.84b | −0.71 | −0.70 | 2.84 (0.10) |
| General Health | 66.9 (12.8) | −15.9 (14.4) | −4.7 (18.9) | −1.24b | −1.10 | −0.84 | 4.46 (0.04) |
| Social Function | 83.6 (26.9) | −19.5 (39.0) | 6.4 (32.8) | −0.72c | −0.50 | −0.59 | 6.10 (0.02) |
| SF-36 composite scores (T-scores) | |||||||
| Physical Health (PCS) | 38.7 (9.8) | −5.7 (10.8) | −0.1 (9.5) | −0.58c | −0.52 | −0.60 | 3.52 (0.07) |
| Mental Health (MCS) | 57.3 (5.0) | −5.3 (10.9) | −0.3 (10.5) | −1.06b | −0.49 | −0.50 | 2.44 (0.13) |
| PDQUALIF (range: 0–100, where 100 is best quality of life) | |||||||
| Social/Role Function | 67.2 (26.4) | −18.4 (22.7) | −1.6 (21.6) | −0.70c | −0.81 | −0.85 | 6.43 (0.02) |
| Self-Image and Sexuality | 62.1 (25.4) | −6.9 (19.0) | 4.3 (19.1) | −0.27d | −0.36 | −0.39 | 3.78 (0.06) |
| Sleep | 71.4 (30.3) | −16.9 (25.9) | −10.4 (27.9) | −0.56c | −0.65 | −0.61 | 0.63 (0.43) |
| Outlook | 66.8 (19.9) | 0.8 (11.8) | 2.5 (10.1) | 0.04 | 0.07 | 0.08 | 0.10 (0.75) |
| Physical Function | 71.6 (21.7) | −4.4 (17.5) | −4.9 (16.6) | −0.20d | −0.25 | −0.27 | 0.01 (0.93) |
| Independence | 84.4 (34.3) | −18.0 (36.2) | 6.4 (37.9) | −0.52c | −0.50 | −0.48 | 4.67 (0.04) |
| Urinary Function | 43.0 (32.6) | −5.5 (35.4) | 1.1 (42.0) | −0.17 | −0.16 | −0.13 | 0.29 (0.59) |
| Total score | 66.6 (17.6) | −9.9 (13.5) | −0.4 (17.2) | −0.56c | −0.73 | −0.58 | 3.83 (0.06) |
| PDQ-39 (range: 0–100, where 100 is best quality of life) | |||||||
| Mobility | 68.9 (27.4) | −13.7 (26.1) | 4.7 (22.8) | −0.50c | −0.52 | −0.60 | 6.59 (0.01) |
| Activities of Daily Living | 64.8 (27.0) | −10.7 (20.5) | 1.8 (26.4) | −0.40d | −0.52 | −0.41 | 2.80 (0.10) |
| Emotional Well-Being | 83.9 (18.3) | −4.9 (8.8) | −3.0 (17.1) | −0.27d | −0.56 | −0.29 | 0.18 (0.67) |
| Stigma | 77.7 (24.4) | 4.3 (18.9) | 13.2 (21.5) | 0.18 | 0.23 | 0.20 | 2.03 (0.16) |
| Social Support | 85.9 (28.5) | −2.1 (20.9) | −0.1 (23.5) | −0.07 | −0.10 | −0.09 | 0.08 (0.78) |
| Cognitions | 75.4 (16.5) | −3.9 (22.6) | −2.1 (13.3) | −0.24d | −0.17 | −0.29 | 0.12 (0.73) |
| Communication | 77.9 (23.2) | −4.2 (17.7) | −5.7 (20.1) | −0.18 | −0.23 | −0.20 | 0.07 (0.79) |
| Bodily Discomfort | 64.6 (24.2) | −2.1 (18.6) | 1.7 (20.9) | −0.09 | −0.11 | −0.10 | 0.38 (0.54) |
| Total score | 74.9 (16.4) | −4.7 (11.5) | 1.3 (13.3) | −0.29d | −0.41 | −0.35 | 2.38 (0.13) |
aDeclined group declined two or more categories from baseline to follow-up (n = 16); Unchanged group had change of one point or less from baseline to follow-up (n = 35). All the scales scored on a 0 (worst) to 100 (best) possible range, except for the SF-36 PCS and MCS, which are T-scores (mean = 50, SD = 10) calculated against a reference population
bLarge effect size (effect size between 0.20 and 0.49)
cMedium effect size (effect size between 0.50 and 0.79)
dSmall effect size (effect size greater than or equal to 0.80)