Fig. 2.

Amino acid sequence of mouse CYP2J6 and a possible epitope recognized by specific CD4⁺ T cells in the context of major histocompatibility complex (MHC) class II. EMTK (284E–287K) was detected from the peptides binding to I-A^k of MIH-2-loaded dendritic cells (DCs) with tandem mass analysis (TMA). D276–K283, adjacent to EMTK on the N-terminal side, possesses the I-A^k binding motif. A peptide consisting of 15 amino acids containing the I-A^k binding motif and EMTK, as indicated by an underline, was synthesized and examined for further biological activity.