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. 2009 May;156(2):363–372. doi: 10.1111/j.1365-2249.2009.03902.x

Fig. 8.

Fig. 8

Circulating antigen-specific immunoglobulin (Ig)G1 and IgG2a levels in non-immunized normal mice (n = 15) and nephrotoxic serum nephritis (NTN) mice treated with 1-methyl-tryptophan (1-MT) (n = 15) or phosphate-buffered saline (PBS) (n = 15). Serum antigen-specific Ig subclass levels were measured by enzyme-linked immunosorbent assay and tested at five dilutions (1:100 to 1:1600) at the end of the experiments. Baseline represents Ig subclass levels in non-immunized normal C57BL/6 mice. (a)IgG1 levels were reduced significantly in 1-MT-treated NTN mice compared with PBS-treated NTN mice (P < 0·01 at all dilutions; while (b) IgG2a levels rose markedly in 1-MT treated NTN mice compared with PBS-treated NTN mice (P < 0·01 at all dilutions).