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Target residues for library construction. Amino acid sequence of the variable regions of D5 heavy chain and light chain are shown with the CDR regions underlined. The target residues that were randomized in the maturation libraries are shown in red bold type. Two libraries were designed for each of the CDR3 regions, with six overlapping codons in each. These libraries are indicated as VH CDR3A&B (DNPTLL, LLGSDY) and VL CDR3A&B (QQYSNY, SNYPLT).
