Table 1. rRNA SNPs in HPL non-cancer and 6 lung cancer cell lines.
| Cell line | Clones with SNP/total (%) | Av # SNPs±S.E. | % clones with 1–2, 3–5, or 6+ SNPs | Multiple clones with same SNPs | Hotspot SNPsc | ||
| 1–2 | 3–5 | 6 or more | |||||
| All lines | 282/362 (77.9) | 2.5±0.3 | 68 | 27 | 5 | −234 (9), −233 (10), −181 (6), −104 (6), −96 (28), −72 (6), +52 (7), +139 (51), + 144 (6), +207 (9), +225 (7), +290 (6) | |
| HPL | 38/51 (74.5) | 2.3±0.2 | 71 | 26 | 3 | +30 & +52 (2)a +21 & +287 (2) | −234 (4), −233 (2), −181 (3), +30 (4), +52 (5), +139 (4) |
| A549 | 47/54 (87.0) | 2.6±0.2 | 53 | 45 | 2 | −96 & +139 (7)b −96, +139, & −62 (2) | −234, −233 (2), −104 (5), −96 (22), +139 (28), +144 (2), +225 |
| H441 | 29/36 (80.6) | 2.3±0.4 | 76 | 17 | 7 | +180 (3), +298 (2) | −233, −234, +139 (7), +144, +225 |
| H23 | 43/48 (89.6) | 2.5±0.3 | 70 | 23 | 7 | +139 (3), +139 & +213 (2) | −234 (2), −233 (2), +139 (7), +207 (9), +225 (3) |
| H1792 | 41/52 (78.8) | 3.1±0.6 | 63 | 27 | 10 | −216 & −40 (2), −182 & −76 (2) | −234, −233, −96 (2), −72, +52, +290 |
| H2030 | 40/56 (71.4) | 2.1±0.3 | 73 | 22 | 5 | −110 (2), −73 (2), +290 (3) | −233, −181 (3), −96 (4), −72 (2), +52, +139 (3), +144 (3), +290 (3) |
| H2122 | 44/65 (67.7) | 2.4±0.2 | 68 | 27 | 5 | None | −233, −104, −72 (3), +139 (2), +225 (2), +290 (2) |
a
2 additional clones had these SNPs plus 3 or 4 others.
b
13 additional clones had these SNPs plus 1 to 4 others.
c
Occurrence in each cell line of clones with SNPs that have significant incidence in that cell line, or in all lines considered together. Multiple clones are indicated in parentheses. Underlined sites are those with a higher number of clones than expected by chance (N≥4), in that cell line.