Figure 4. Structural Mapping of nsSNPs onto the Kinase Catalytic Domain.

Structural mapping is shown for common nsSNPs (A), disease-causing nsSNPs (B), and cancer-causing nsSNPs (C). In all panels the green coloration represents regions with a SNP frequency equivalent to what would be expected by random chance, blue coloration represents regions that are statistically devoid of SNPs, and red coloration depicts regions that are statistically enriched in SNPs. Enrichment of SNPs in these regions was calculated as described in the Materials and Methods section. For clarity, the SNPs density was mapped onto a representative kinase crystal structure (EGFR, pdb entry 1M14) by projecting the multiple sequence kinase alignment onto the protein structure.