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. 2009 Oct 19;4(10):e7486. doi: 10.1371/journal.pone.0007486

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Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: Effects of NR2A-selective antagonist, NVP-AAM077, on wild-type slices. B: NVP-AAM077 also significantly reduced, but not completely blocked, CA1 LTP in transgenic slices. C: Statistical analysis shows the effects of NVP-AAM077 on LTP in both Tg and Wt slice. It indicates a significant involvement of NR2A-containing NMDARs in CA1-LTP induction in both Tg and WT slices. D: There was a significant, but small, effect of NR2B-selective antagonist, Ro25-6981, on CA1-LTP in wild-type slices. E: Ro25-6981 had much larger effect on CA1-LTP in transgenic slices, but it did not completely block LTP in transgenic slices. F: Summarized effects of Ro25-6981 on CA1-LTP in both Tg and Wt slice. G: Combination of NVP-AAM077 and Ro25-6981 completely blocked the formation of CA3-CA1 LTP completely in the wild-type slices. H: Complete blockage of CA1-LTP in transgenic slices by combined application of NVP-AAM077 and Ro25-6981. I: Statistical analysis shows the combined effects of NVP-AAM077 and Ro25-6981 on CA1-LTP. (Data were presented as the mean±SEM. Student's t-test was used for statistical analysis).