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. 2009 Aug 19;64A(11):1146–1153. doi: 10.1093/gerona/glp118

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Published by Oxford University Press on behalf of The Gerontological Society of America 2009.

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Figure 3. — Immunohistochemistry analysis of selected claudins in aging mouse pancreas. (A) Representative staining for claudin-4 from pancreas sections of 6- and 24-month-old male mice. Claudin-4 is clearly reduced in older mice. (B) Effects of aging on the expression of the indicated claudins. Results shown were quantitated using the MCID image analysis software and represent the average of nine sections (three pancreas punches from three mice) (*p < .05, **p < .001; brackets show the significance between age groups (both male and female) and the absence of a bracket indicates significance for one gender within the age group). The staining data are shown as arbitrary units (A.U.). Results are shown for 6- and 24-month-old mice. Black bars represent males and gray bars females. Claudin-1, -3, -4, and -5, and claudin-4 were significantly decreased in both male and female mice. Claudin-2 and -7 were significantly decreased in females. (C) The effect of age and gender on claudin expression in mouse liver. The expression of the indicated claudins was examined in the liver of 1-month-old (1M), 6-month-old (6M), 16-month-old (16M), and 24-month-old (24M) mice. All the claudin examined tended to be decreased in the pancreas of older mice.